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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737278
Species: Mus musculus
RGD Object: Gene
Symbol: Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Acc ID: CHEBI:63619
Term: propafenone
Definition: An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Chemical ID: MESH:D011405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a1multiple interactionsISOSLC22A1 (Homo sapiens)6480464CTDPropafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:21641380
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