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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732102
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Acc ID: CHEBI:63619
Term: propafenone
Definition: An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Chemical ID: MESH:D011405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects activityISOKCNH2 (Homo sapiens)6480464CTDPropafenone affects the activity of KCNH2 proteinPMID:16278312
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDPropafenone results in decreased activity of KCNH2 proteinPMID:18724381 PMID:24052561
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDPropafenone analog binds to and results in decreased activity of KCNH2 protein; Propafenone binds to and results in decreased activity of KCNH2 protein; Propafenone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]PMID:21158687 PMID:21175572
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