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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736496
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPT
Name: microtubule associated protein tau
Acc ID: CHEBI:63618
Term: pravastatin
Definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Chemical ID: MESH:D017035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPTaffects expressionEXP 6480464CTDPravastatin affects the expression of MAPTPMID:19461118
MAPTdecreases expressionISOMapt (Rattus norvegicus)6480464CTDPravastatin results in decreased expression of MAPT mRNAPMID:27225895
MAPTdecreases expressionISOMapt (Mus musculus)6480464CTDPravastatin results in decreased expression of MAPT mRNAPMID:27225895
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