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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2177
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp4a
Name: ATPase H+/K+ transporting subunit alpha
Acc ID: CHEBI:63618
Term: pravastatin
Definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Chemical ID: MESH:D017035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDPravastatin results in decreased expression of ATP4A mRNA

PMID:27225895
decreases expressionISORGD:102126480464CTDPravastatin results in decreased expression of ATP4A mRNA

PMID:27225895
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.