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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731073
Species: Mus musculus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:63580
Term: ribavirin
Definition: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.
Chemical ID: MESH:D012254
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases secretionEXP 6480464CTDRibavirin results in decreased secretion of VEGFA proteinPMID:34919946
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDRibavirin results in decreased expression of VEGFA mRNA; Ribavirin results in decreased expression of VEGFA proteinPMID:29112301 PMID:34919946
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDRibavirin inhibits the reaction [CARM1 protein binds to VEGFA promoter]PMID:34919946
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