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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876
Species: Mus musculus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:63577
Term: lamivudine
Definition: A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.
Chemical ID: MESH:D019259
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpldecreases expressionEXP 6480464CTDLamivudine results in decreased expression of LPL mRNAPMID:11741158
Lplmultiple interactionsEXP 6480464CTD[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNA; [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNAPMID:11741158
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