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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628693
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npc1
Name: NPC intracellular cholesterol transporter 1
Acc ID: CHEBI:63112
Term: fingolimod hydrochloride
Definition: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Chemical ID: MESH:D000068876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npc1increases expressionISONPC1 (Homo sapiens)6480464CTDFingolimod Hydrochloride results in increased expression of NPC1 proteinPMID:20056921
Npc1multiple interactionsISONPC1 (Homo sapiens)6480464CTDNPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]PMID:20056921
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