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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731644
Species: Homo sapiens
RGD Object: Gene
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RPS6KB1decreases phosphorylationEXP 6480464CTDmanganese chloride results in decreased phosphorylation of RPS6KB1 proteinPMID:30578841
RPS6KB1multiple interactionsEXP 6480464CTDcorynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of RPS6KB1 protein]PMID:30578841
RPS6KB1decreases phosphorylationISORps6kb1 (Rattus norvegicus)6480464CTDmanganese chloride results in decreased phosphorylation of RPS6KB1 proteinPMID:23604964
RPS6KB1increases phosphorylationISORps6kb1 (Rattus norvegicus)6480464CTDmanganese chloride results in increased phosphorylation of RPS6KB1 proteinPMID:15342272
RPS6KB1multiple interactionsISORps6kb1 (Mus musculus)6480464CTD[[manganese chloride results in increased abundance of Manganese] which co-treated with Sirolimus] results in decreased phosphorylation of RPS6KB1 proteinPMID:31690173
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