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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2increases activityEXP 6480464CTDmanganese chloride results in increased activity of SOD2 proteinPMID:27701121
SOD2increases expressionEXP 6480464CTDmanganese chloride results in increased expression of SOD2 mRNA; manganese chloride results in increased expression of SOD2 proteinPMID:10328827 PMID:17175027
SOD2multiple interactionsEXP 6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [manganese chloride results in increased expression of SOD2 protein]; Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 protein]; manganese chloride inhibits the reaction [Glucose results in decreased activity of SOD2 protein]; Pyruvates inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; Pyruvates inhibits the reaction [manganese chloride results in increased expression of SOD2 protein]PMID:10328827 PMID:23329836
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDmanganese chloride results in decreased expression of SOD2 proteinPMID:24969583 PMID:25288107
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDmanganese chloride results in decreased expression of SOD2 proteinPMID:15922012
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDmanganese chloride results in increased expression of SOD2 proteinPMID:22154916
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTD[Plant Extracts co-treated with manganese chloride] results in increased expression of SOD2 protein; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]PMID:25288107 PMID:26064043
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