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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDmanganese chloride results in increased expression of BAX mRNA; manganese chloride results in increased expression of BAX proteinPMID:17623882 PMID:25732873
Baxmultiple interactionsEXP 6480464CTD[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; manganese chloride results in increased expression of and affects the localization of BAX proteinPMID:21704098 PMID:30844427 PMID:30951808 PMID:33314588
Baxincreases expressionISOBax (Mus musculus)6480464CTDmanganese chloride results in increased expression of BAX proteinPMID:29183790
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; Estradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein]; Tamoxifen inhibits the reaction [manganese chloride results in increased expression of BAX protein]PMID:26064043 PMID:29183790 PMID:31676349 PMID:35690225
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDNTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]PMID:31676349
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