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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310568
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp2
Name: poly (ADP-ribose) polymerase 2
Acc ID: CHEBI:62880
Term: veliparib
Definition: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
Chemical ID: MESH:C521013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp2affects bindingISOPARP2 (Homo sapiens)6480464CTDPARP2 protein binds to veliparibPMID:20092359
Parp2decreases activityISOPARP2 (Homo sapiens)6480464CTDveliparib results in decreased activity of PARP2 proteinPMID:19143569 PMID:21917757
Parp2multiple interactionsISOPARP2 (Homo sapiens)6480464CTDveliparib binds to and results in decreased activity of PARP2 proteinPMID:28001384
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