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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:62845
Term: 4-hydroxy-17beta-estradiol
Definition: A 4-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 4.
Chemical ID: MESH:C014036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTaffects metabolic processingEXP 6480464CTDCOMT protein affects the metabolism of 4-hydroxyestradiolPMID:15377160
COMTincreases methylationEXP 6480464CTDCOMT protein results in increased methylation of 4-hydroxyestradiolPMID:18192686
COMTmultiple interactionsEXP 6480464CTDdaidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]PMID:18192686
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