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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731503
Species: Homo sapiens
RGD Object: Gene
Symbol: ROCK2
Name: Rho associated coiled-coil containing protein kinase 2
Acc ID: CHEBI:61668
Term: oroxylin A
Definition: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.
Chemical ID: MESH:C080669
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ROCK2multiple interactionsISORock2 (Rattus norvegicus)6480464CTD[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein]PMID:26694894
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