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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69152
Species: Homo sapiens
RGD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:61399
Term: canertinib
Definition: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.
Chemical ID: MESH:C420268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFRdecreases activityEXP 6480464CTDCanertinib results in decreased activity of EGFR protein; Canertinib results in decreased activity of EGFR protein mutant formPMID:21322567
EGFRdecreases phosphorylationEXP 6480464CTDCanertinib results in decreased phosphorylation of EGFR proteinPMID:15956251
EGFRmultiple interactionsEXP 6480464CTDCanertinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]PMID:18927496
EGFRmultiple interactionsISOEgfr (Mus musculus)6480464CTDCanertinib inhibits the reaction [Acetaminophen affects the localization of EGFR protein]; Canertinib inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein]PMID:28123000
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