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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619796
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cysltr1
Name: cysteinyl leukotriene receptor 1
Acc ID: CHEBI:6129
Term: ketorolac
Definition: A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
Chemical ID: MESH:D020910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cysltr1multiple interactionsISORGD:7325246480464CTDKetorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]

PMID:19767084
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