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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:6129
Term: ketorolac
Definition: A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
Chemical ID: MESH:D020910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTD[Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA] Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA] Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA] Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone]

PMID:10800959
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