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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDKetamine results in increased expression of IL6 mRNA; Ketamine results in increased expression of IL6 proteinPMID:15207037 PMID:15207038 PMID:33536391
Il6multiple interactionsEXP 6480464CTDTRPV4 protein affects the reaction [Ketamine results in increased expression of IL6 protein]PMID:33536391
Il6affects response to substanceISOIl6 (Mus musculus)6480464CTDIL6 affects the susceptibility to KetaminePMID:19091984
Il6increases expressionISOIl6 (Mus musculus)6480464CTDKetamine results in increased expression of IL6 mRNA; Ketamine results in increased expression of IL6 proteinPMID:19091984 PMID:23087136 PMID:34487425
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]; Ketamine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein]PMID:19540866 PMID:22245128 PMID:23087136 PMID:37491939
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDKetamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]PMID:15720977
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