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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2652
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1decreases expressionISOGad1 (Mus musculus)6480464CTDKetamine results in decreased expression of GAD1PMID:18063801
Gad1increases expressionISOGad1 (Mus musculus)6480464CTDKetamine results in increased expression of GAD1 mRNAPMID:23660488
Gad1multiple interactionsISOGad1 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein]PMID:18063801
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