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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDKetamine results in increased expression of BAX mRNA; Ketamine results in increased expression of BAX proteinPMID:18456338 PMID:25937004 PMID:33536391 PMID:36305173
Baxmultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX protein]PMID:33536391 PMID:36305173
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDKetamine affects the localization of BAX proteinPMID:19001360
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