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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9increases cleavageEXP 6480464CTDbelinostat results in increased cleavage of CASP9 proteinPMID:18223231 PMID:25537862
CASP9multiple interactionsEXP 6480464CTDBortezomib promotes the reaction [belinostat results in increased cleavage of CASP9 protein]PMID:18223231
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