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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619652
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a6bmultiple interactionsISOUGT1A6 (Homo sapiens)6480464CTDbelinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]PMID:33290829
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