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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16024026480464CTDbelinostat results in decreased expression of ARHGEF37 mRNA

PMID:26272509
multiple interactionsISORGD:16024026480464CTD[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF37 mRNA

PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.