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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:61058
Term: alpha-methyl-L-dopa
Definition: A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.
Chemical ID: MESH:D008750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTdecreases activityEXP 6480464CTDMethyldopa results in decreased activity of COMT proteinPMID:7053299
COMTincreases methylationEXP 6480464CTDCOMT protein results in increased methylation of MethyldopaPMID:11160877
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