GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL2 | decreases expression | EXP | | 6480464 | CTD | Tacrolimus results in decreased expression of IL2 protein | PMID:11407316 | IL2 | multiple interactions | EXP | | 6480464 | CTD | [Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Tacrolimus inhibits the reaction [Zinc Sulfate inhibits the reaction [Mitogens results in increased expression of IL2 mRNA]] | PMID:1371491 PMID:16055081 PMID:1705513 PMID:24603311 PMID:29594315 | IL2 | decreases expression | ISO | Il2 (Rattus norvegicus) | 6480464 | CTD | Tacrolimus results in decreased expression of IL2 mRNA | PMID:12126653 | IL2 | decreases expression | ISO | Il2 (Mus musculus) | 6480464 | CTD | Tacrolimus results in decreased expression of IL2 mRNA; Tacrolimus results in decreased expression of IL2 protein | PMID:1701765 PMID:8986461 | IL2 | multiple interactions | ISO | Il2 (Mus musculus) | 6480464 | CTD | Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2 protein]; Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]] | PMID:1614535 PMID:25770929 | | ||||||||||||||||||||||
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