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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:61057
Term: tacrolimus hydrate
Definition: A hydrate that is the monohydrate form of tacrolimus.
Chemical ID: MESH:D016559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1increases activityISONr3c1 (Mus musculus)6480464CTDTacrolimus results in increased activity of NR3C1 proteinPMID:15697228
Nr3c1multiple interactionsISONr3c1 (Mus musculus)6480464CTDTacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein]; Tacrolimus promotes the reaction [Dexamethasone binds to NR3C1 protein]; Tacrolimus promotes the reaction [NR3C1 protein binds to PPP5C protein]PMID:15697228
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