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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:60888
Term: BAPTA
Definition: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.
Chemical ID: MESH:C025603
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD1, 2-bis(2-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein], [Egtazic Acid co-treated with 1, 2-bis(2-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid] inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]

PMID:29111403
increases expressionISORGD:691656480464CTD1, 2-bis(2-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid results in increased expression of DDIT3 protein

PMID:28181380
multiple interactionsISORGD:691656480464CTD1, 2-bis(2-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein]

PMID:28181380
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.