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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736865
Species: Homo sapiens
RGD Object: Gene
Symbol: FGFR2
Name: fibroblast growth factor receptor 2
Acc ID: CHEBI:60782
Term: fluprostenol
Definition: An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.
Chemical ID: MESH:C006326
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FGFR2decreases expressionISOFgfr2 (Rattus norvegicus)6480464CTDfluprostenol results in decreased expression of FGFR2 mRNAPMID:15654655
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