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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2rx4
Name: purinergic receptor P2X 4
Acc ID: CHEBI:6078
Term: ivermectin
Definition: A mixture consisting of >= 90% 22,23-dihydroavermectin B1a (R = Me) and <= 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Chemical ID: MESH:D007559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2rx4increases activityISOP2rx4 (Mus musculus)6480464CTDIvermectin results in increased activity of P2RX4 proteinPMID:19560503
P2rx4multiple interactionsISOP2rx4 (Mus musculus)6480464CTDIvermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]PMID:21638035
P2rx4multiple interactionsISOP2RX4 (Homo sapiens)6480464CTDIvermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]PMID:30545933
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