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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2rx4
Name: purinergic receptor P2X 4
Acc ID: CHEBI:6078
Term: ivermectin
Definition: A mixture consisting of >= 90% 22,23-dihydroavermectin B1a (R = Me) and <= 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Chemical ID: MESH:D007559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:623656480464CTDIvermectin results in increased activity of P2RX4 protein

PMID:19560503
multiple interactionsISORGD:623656480464CTDIvermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

PMID:21638035
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.