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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:6067
Term: isotretinoin
Definition: A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
Chemical ID: MESH:D015474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDIsotretinoin results in decreased expression of BCL2; Isotretinoin results in decreased expression of BCL2 mRNA; Isotretinoin results in decreased expression of BCL2 proteinPMID:18380168 PMID:18652567 PMID:27606422
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDIsotretinoin results in decreased expression of BCL2; Isotretinoin results in decreased expression of BCL2 proteinPMID:16109544 PMID:16909596
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDIsotretinoin results in increased expression of BCL2 mRNA; Isotretinoin results in increased expression of BCL2 proteinPMID:21159604
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