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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDIsoniazid results in increased expression of BAX proteinPMID:33121995
Baxmultiple interactionsEXP 6480464CTDchrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]PMID:33121995
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDIsoniazid affects the expression of BAX proteinPMID:20433247
Baxincreases expressionISOBax (Mus musculus)6480464CTDIsoniazid results in increased expression of BAX mRNAPMID:33771660
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDIsoniazid results in increased expression of BAX proteinPMID:31332904
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]PMID:21419764
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDQuercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein]PMID:31332904
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