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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcdecreases expressionEXP 6480464CTDIsoniazid results in decreased expression of GCLC mRNAPMID:24128855
Gclcincreases expressionEXP 6480464CTDIsoniazid results in increased expression of GCLC mRNAPMID:33771660
Gclcmultiple interactionsEXP 6480464CTDIsoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]PMID:24128855
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDIsoniazid results in increased expression of GCLC mRNAPMID:33121995
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTDchrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]PMID:33121995
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