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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319783
Species: Mus musculus
RGD Object: Gene
Symbol: Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
Acc ID: CHEBI:60151
Term: oxidised LDL
Definition: An oxidised form of low-density lipoprotein (LDL), regulated in vivo by a complex set of biochemical reactions and chiefly stimulated by the presence of necrotic cell debris and free radicals in the endothelium.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k7increases phosphorylationISOMAP3K7 (Homo sapiens)155804296RGDOxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells 
Map3k7multiple interactionsISOMAP3K7 (Homo sapiens)155804296RGDAlbiflorin inhibits the reaction [oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells] 
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