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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:59990
Term: N,N-dimethyl-4-nitrosoaniline
Definition: A member of the class of dimethylanilines that is N,N-dimethylaniline having a nitroso group at the 4-position.
Chemical ID: MESH:C008651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtdecreases expressionEXP 6480464CTD4-nitrosodimethylaniline results in decreased expression of MGMT proteinPMID:15542103
Mgmtdecreases expressionISOMGMT (Homo sapiens)6480464CTD4-nitrosodimethylaniline results in decreased expression of MGMT proteinPMID:15542103
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