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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732174
Species: Homo sapiens
RGD Object: Gene
Symbol: BCHE
Name: butyrylcholinesterase
Acc ID: CHEBI:59849
Term: ecothiopate iodide
Definition: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Chemical ID: MESH:D004456
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCHEdecreases activityEXP 6480464CTDEchothiophate Iodide results in decreased activity of BCHE proteinPMID:16213467 PMID:17698511 PMID:21802514 PMID:7377577
BCHEmultiple interactionsEXP 6480464CTDEchothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]PMID:21802514
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