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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:5981
Term: isoalantolactone
Definition: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.
Chemical ID: MESH:C032787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases cleavageISORGD:12983476480464CTDisoalantolactone results in increased cleavage of CASP7 proteinPMID:29800641
Casp7increases expressionISORGD:12983476480464CTDisoalantolactone results in increased expression of CASP7 protein modified formPMID:29800641
Casp7multiple interactionsISORGD:12983476480464CTDAcetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]PMID:29800641
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