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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:5981
Term: isoalantolactone
Definition: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.
Chemical ID: MESH:C032787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISORGD:13451186480464CTDisoalantolactone results in increased cleavage of PARP1 protein

PMID:29800641
Parp1increases expressionISORGD:13451186480464CTDisoalantolactone results in increased expression of PARP1 protein modified form

PMID:29800641
Parp1multiple interactionsISORGD:13451186480464CTDAcetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form] benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form] TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]

PMID:29800641
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