GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c65 | increases chemical synthesis | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 protein results in increased chemical synthesis of 4'-hydroxydiclofenac | PMID:12401345 PMID:15155557 | Cyp2c65 | multiple interactions | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac] which affects the abundance of 4'-hydroxydiclofenac; [CYP2C9 mRNA results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased hydroxylation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] | PMID:24104198 PMID:24246759 PMID:25084468 PMID:29555536 PMID:31854189 PMID:35366062 PMID:35748891 | | ||||||||||||||||||||||
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