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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61992
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gch1
Name: GTP cyclohydrolase 1
Acc ID: CHEBI:59560
Term: sapropterin
Definition: A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer).
Chemical ID: MESH:C003402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gch1affects abundanceISORGD:15512456480464CTDGCH1 protein affects the abundance of sapropterin

PMID:21963838
Gch1decreases abundanceISORGD:13457396480464CTDGCH1 mutant form results in decreased abundance of sapropterin

PMID:25041251
Gch1increases chemical synthesisISORGD:13457396480464CTDGCH1 protein results in increased chemical synthesis of sapropterin

PMID:14551046
Gch1multiple interactionsISORGD:13457396480464CTDEPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]

PMID:25041251
Gch1multiple interactionsISORGD:15512456480464CTD[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin [Resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin] GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin

PMID:20610621 PMID:25490417
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