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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736996
Species: Homo sapiens
RGD Object: Gene
Symbol: PTHLH
Name: parathyroid hormone like hormone
Acc ID: CHEBI:59219
Term: ceruletide
Definition: A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.
Chemical ID: MESH:D002108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTHLHincreases expressionEXP 6480464CTDCeruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH proteinPMID:25035110
PTHLHmultiple interactionsEXP 6480464CTDPTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]PMID:25035110
PTHLHaffects response to substanceISOPthlh (Rattus norvegicus)6480464CTDPTHLH protein affects the susceptibility to CeruletidePMID:22280800
PTHLHincreases expressionISOPthlh (Mus musculus)6480464CTDCeruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH proteinPMID:22280800 PMID:25035110
PTHLHincreases expressionISOPthlh (Rattus norvegicus)6480464CTDCeruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH proteinPMID:22280800
PTHLHmultiple interactionsISOPthlh (Mus musculus)6480464CTDPTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]PMID:25035110
PTHLHmultiple interactionsISOPthlh (Rattus norvegicus)6480464CTDEthanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]PMID:22280800
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