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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2
Name: coagulation factor II
Acc ID: CHEBI:59173
Term: bivalirudin
Definition: A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.
Chemical ID: MESH:C074619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2decreases activityISORGD:13532566480464CTDbivalirudin results in decreased activity of F2 protein

PMID:1290488, PMID:19644995, PMID:8456428
F2increases cleavageISORGD:13532566480464CTDF2 protein results in increased cleavage of bivalirudin

PMID:1290488
F2multiple interactionsISORGD:13532566480464CTDbivalirudin binds to and results in decreased activity of F2 protein, bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein]

PMID:15080313, PMID:15155122, PMID:16084352, PMID:16845256, PMID:17696810, PMID:18449412, PMID:19124943
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.