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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:59059
Term: methyl isocyanate
Definition: The isocyanate that is methane modified by a single isocyanato substituent.
Chemical ID: MESH:C008461
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtdecreases activityISOMGMT (Homo sapiens)6480464CTDmethyl isocyanate results in decreased activity of MGMT proteinPMID:14685775
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