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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:59020
Term: alpha-methyltryptamine
Definition: A tryptamine derivative having a methyl substituent at the alpha-position.
Chemical ID: MESH:C015293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDindopan analog results in decreased activity of CYP2E1 protein; indopan results in decreased activity of CYP2E1 proteinPMID:26599973
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of ChlorzoxazonePMID:26599973
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