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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDSildenafil Citrate results in increased phosphorylation of AKT1 proteinPMID:18373738
Akt1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDSildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA]; Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]PMID:35608386 PMID:36940862
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