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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10118
Species: Mus musculus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtmultiple interactionsEXP 6480464CTDPRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]PMID:25139994
Agtincreases expressionISOAGT (Homo sapiens)6480464CTDSildenafil Citrate results in increased expression of AGT protein modified formPMID:15613622
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