GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | decreases activity | EXP | | 6480464 | CTD | Ibuprofen results in decreased activity of PTGS2 protein; Ibuprofen results in decreased activity of PTGS2 protein mutant form | PMID:17164136 PMID:18848576 PMID:22245433 | PTGS2 | increases expression | EXP | | 6480464 | CTD | Ibuprofen results in increased expression of PTGS2 mRNA | PMID:16678543 | PTGS2 | increases response to substance | EXP | | 6480464 | CTD | PTGS2 gene SNP results in increased susceptibility to Ibuprofen | PMID:16678543 | PTGS2 | multiple interactions | EXP | | 6480464 | CTD | Ibuprofen inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Ibuprofen inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] | PMID:15489888 PMID:15705740 PMID:18297109 PMID:34755645 | PTGS2 | decreases activity | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ibuprofen results in decreased activity of PTGS2 protein | PMID:12242329 | PTGS2 | decreases degradation | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ibuprofen results in decreased degradation of PTGS2 protein | PMID:19758985 | PTGS2 | decreases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Ibuprofen results in decreased expression of PTGS2 mRNA | PMID:10697514 PMID:16249722 | PTGS2 | decreases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ibuprofen results in decreased expression of PTGS2 mRNA; Ibuprofen results in decreased expression of PTGS2 protein | PMID:15817521 PMID:29222744 PMID:37453669 | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Ibuprofen results in increased expression of PTGS2 mRNA | PMID:18096423 | PTGS2 | multiple interactions | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Ibuprofen inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] | PMID:16997862 PMID:21360558 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | [Dexamethasone co-treated with Ibuprofen] results in decreased expression of PTGS2 mRNA; [Ibuprofen binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 | PMID:26359731 PMID:29222744 | | ||||||||||||||||||||||
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