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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730892
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKB1multiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen results in decreased activity of [NFKB1 protein binds to RELA protein]PMID:10602496 PMID:15489888 PMID:9890559
NFKB1multiple interactionsISONfkb1 (Mus musculus)6480464CTDIbuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]PMID:9281604
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