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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1increases activityEXP 6480464CTDIbuprofen results in increased activity of NR3C1 proteinPMID:15700047
Nr3c1decreases expressionISONR3C1 (Homo sapiens)6480464CTDIbuprofen results in decreased expression of NR3C1 mRNAPMID:25596134
Nr3c1multiple interactionsISONr3c1 (Mus musculus)6480464CTDNR3C1 protein affects the reaction [Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]]PMID:29222744
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