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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDIbuprofen results in increased expression of UGT1A1 mRNA

PMID:29222744
multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA

PMID:29222744
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of Ibuprofen

PMID:15843492
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.