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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11315
Species: Mus musculus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Acc ID: CHEBI:5852
Term: ibogaine
Definition: An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a methoxy group.
Chemical ID: MESH:D007050
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3increases expressionISOSLC6A3 (Homo sapiens)6480464CTDIbogaine results in increased expression of SLC6A3 proteinPMID:27555326
Slc6a3multiple interactionsISOSLC6A3 (Homo sapiens)6480464CTDIbogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]PMID:27555326
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