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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:5834
Term: hyperforin
Definition: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.
Chemical ID: MESH:C001654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases cleavageEXP 6480464CTDhyperforin results in increased cleavage of CASP3 proteinPMID:32485087
CASP3multiple interactionsEXP 6480464CTDhyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]PMID:30481499
CASP3decreases expressionISOCasp3 (Rattus norvegicus)6480464CTDhyperforin results in decreased expression of CASP3 mRNAPMID:30481499
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDhyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]; hyperforin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]PMID:30481499 PMID:36640868
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